GENERAL CATALOGUE
GSK-872 hydrochloride
HY-101872A · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-101872A
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medchemexpress.com/gsk-872-hydrochloride.html
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Catalog No: HY-101872A
CAS No: 2703752-81-0
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.