GENERAL CATALOGUE
Givosiran sodium
HY-132610A · 1 mg
MedChemExpress · Cat: HY-132610A
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medchemexpress.com/givosiran-sodium.htmlCatalog No: HY-132610A
CAS No: 1639325-44-2
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
Givosiran ALN-AS1 sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 ALAS1 messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic ?-aminolevulinic acid ALA and porphobilinogen PBG levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria AHP .