Fluorofenidone-d3

Description

Fluorofenidone-d3 AKF-PD-d3 is deuterium labeled Fluorofenidone AKF-PD HY-121246 . Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-?B signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgf?1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease COPD , pulmonary interstitial fibrosis PIF and non-small cell lung cancer NSCLC .