
ab141930 · 10 mg
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Description
MW 429.9 Da, Purity >98 %. Potent EGFR tyrosine kinase inhibitor IC50 = 2 nM . Decreases EGFR autophosphorylation in tumor cells. Potent inhibitor of mutant JAK2-V617F. Weaker inhibitor of ErbB-2 kinase Ki = 1 muM and ErbB-4 kinase Ki = 1.5 muM . Clinically effective agent for non-small cell lung cancer NSCLC .






