Embelin, cell-permeable inhibitor of X-linked inhibitor of apoptosis

Description

MW 294.4 Da, Purity >98 %. Potent, cell-permeable inhibitor of X-linked inhibitor of apoptosis XIAP IC50 = 4.1 muM . Binds to the XIAP BIR3 protein and interacts with residues crucial for Smac and caspsase-9 binding. Inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells IC50 = 3.7 - 5.7 muM ; minimal effects on normal prostate cells IC50 = 19.3 - 20.1 muM . Antitumor and anti-inflammatory effects in vivo.