GENERAL CATALOGUE
EGFR/AURKB-IN-1
HY-157480 · 5 mg
MedChemExpress · Cat: HY-157480
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Catalog No: HY-157480
CAS No: 3008543-34-5
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
EGFR/AURKB-IN-1 compound 7 is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the ?C-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research.