GENERAL CATALOGUE
DT2216
HY-130604 · 1 mg
MedChemExpress · Cat: HY-130604
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Manufacturer product page
medchemexpress.com/dt2216.htmlCatalog No: HY-130604
CAS No: 2365172-42-3
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
DT2216 is a potent and selective BCL-XL Bcl-2 family member degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau VHL E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax-piperazine HY-44432 , a linker, and a VHL E3 ubiquitin ligase Pink: Navitoclax-piperazine; Blue: VHL ligand; Black: linker .
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