GENERAL CATALOGUE
DPI-4452
HY-P10761 · 1 mg
MedChemExpress · Cat: HY-P10761
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Catalog No: HY-P10761
CAS No: 2941391-49-5
Category: Antibody-drug Conjugate ADC Related
Pack Size: 1 mg
Brand: MedChemExpress
Description
DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets IC50 for recombinant hCAIX: 130 nM . Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models. DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates RDCs .
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