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Dabrafenib, mutant B-Raf V600E inhibitor
ab222019 · 5 mg
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Catalog No: ab222019
Category: Biochemicals
Pack Size: 5 mg
Brand: abcam
Description
MW 519.6 Da, Purity >98 %. Potent, ATP-competitive mutant B-Raf V600E inhibitor IC50 = 0.7 nM , with selectivity versus wild-type B-Raf IC50 = 5.2 nM and c-RAf IC50 = 6.3 nM in cell-free assays. Antitumor activity in vivo in mouse models of B-Raf V600E melanoma.
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