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D-?-Hydroxyglutaric acid
GENERAL CATALOGUE

D-?-Hydroxyglutaric acid

HY-113038 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-113038

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Catalog No: HY-113038
CAS No: 13095-47-1
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

D-?-Hydroxyglutaric acid R -2-Hydroxyglutarate is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-?-Hydroxyglutaric acid is a weak competitive antagonist of ?-ketoglutarate ?-KG and inhibits multiple ?-KG-dependent dioxygenases with a Ki of 10.87 mM. D-?-Hydroxyglutaric acid increases reactive oxygen species ROS production. D-?-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.

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