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CUR 61414, Hedgehog signaling pathway antagonist
ab222964 · 5 mg
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Catalog No: ab222964
Category: Biochemicals
Pack Size: 5 mg
Brand: abcam
Description
MW 550.7 Da, Purity >98 %. Novel, cell permeable Hedgehog signaling pathway antagonist IC50 = 100-200 nM . Selectively binds to smoothened Smo Ki = 44 nM . Blocks the formation of and induces the regression of basaloid lesions in skin punches and shrinks UV-induced basaloid lesions in adult mouse skin. Inhibits proliferation and induces apoptosis in tumor cells without affecting non-tumor cells.
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