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Crizotinib-d8
GENERAL CATALOGUE

Crizotinib-d8

HY-50878S1 · 50 mg

MedChemExpress · Cat: HY-50878S1

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medchemexpress.com/crizotinib-d8.html
Catalog No: HY-50878S1
CAS No: 1523579-82-9
Category: Autophagy
Pack Size: 50 mg
Brand: MedChemExpress

Description

Crizotinib-d8 PF-02341066-d8 is deuterium labeled Crizotinib. Crizotinib PF-02341066 is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.

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