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Crenolanib (CP-868596)
ab273385 · 5 mg
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Catalog No: ab273385
Category: Biochemicals
Pack Size: 5 mg
Brand: abcam
Description
MW 443.5 Da, Purity 97 %. Potent inhibitor of PDGFR Kd for alpha = 2.1 nM; beta = 3.2 nM and FLT3 Kd = 0.74 nM . Type I inhibitor that binds only the active kinase conformation. Active towards imatinib-resistance assciated PDGFR-alpha mutations D842I, D842V, D842Y, DI842-843M, and deletion I843 . Active against FLT3/ITD and FLY3/D835 mutatants. Over 100-fold selective for PDGFR versus c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.
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