GENERAL CATALOGUE
CRBN-6-5-5-VHL
HY-136262 · 5 mg
MedChemExpress · Cat: HY-136262
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Catalog No: HY-136262
CAS No: 2362575-45-7
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
CRBN-6-5-5-VHL is a potent and selective von Hippel-Lindau-based cereblon CRBN degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3. Pink: VHL ligand HY-125845 ; Blue: E3 Ligase ligand HY-10984 ; Black: linker HY-403544 .
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