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CHZ868
ab287065 · 5 mg
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Catalog No: ab287065
Category: Biochemicals
Pack Size: 5 mg
Brand: abcam
Description
MW 423.4 Da, Purity >98 %. CHZ868 is a potent and selective type II JAK2 inhibitor IC50 = 110 nM . JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces reductions in mutant allele burden not observed with type I JAK inhibitors.
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