CDK4/6/HDAC-IN-1

Description

CDK4/6/HDAC-IN-1 Compound N14 is a dual-targeting inhibitor of CDK4/6 and HDAC IC50: CDK4 = 7.23 nM, CDK6 = 13.20 nM, HDAC1 = 55.66 nM, HDAC6 = 48.38 nM . CDK4/6/HDAC-IN-1 induces cell Apoptosis and G0/G1 phase arrest through HDAC-p21-CDK signaling pathway. CDK4/6/HDAC-IN-1 inhibits hepatocellular carcinoma.