GENERAL CATALOGUE
BMH-22
HY-118723 · 5 mg
MedChemExpress · Cat: HY-118723
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medchemexpress.com/bmh-22.htmlCatalog No: HY-118723
CAS No: 309726-06-5
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
BMH-22, a benzonaphthyridin, is a RNA polymerase I Pol I transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types.