Bax/Bak Double Knockout Immortalized Mouse Kidney Epithelial Cell Line

Description

Key regulators of apoptosis, such as members of the BCL-2 family, have long been linked to the development of cancer. The Bax/Bak Double Knockout Immortalized Mouse Kidney Epithelial Cells bax-/-/ bak-/- iBMK is derived from stable transformation of E1A and p53DD into primary baby kidney epithelial cells from C57B/6J mice deficient for Bak and Bax. Bax and Bak are functionally redundant downstream regulators to the mechanism of apoptosis, therefore this double knockdown cell line provides a valuable insight into pro-apoptotic proteins and programmed cell death. Together with the wild-type iBMK T0082 , Bax knockout iBMK bax-/- iBMK, T3024 and Bak Knockout iBMK Bak-/- iBMK, T3025 , these cell lines are suitable in studying the relationships between BCL-2 family and cancer progression, prognosis and significance to treatment.