GENERAL CATALOGUE
AZ10397767
HY-124056 · 5 mg
MedChemExpress · Cat: HY-124056
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medchemexpress.com/az10397767.htmlCatalog No: HY-124056
CAS No: 333742-63-5
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
AZ10397767 is an orally active, selective CXCR2 receptor antagonist with an IC50 of 1 nM. AZ10397767 attenuates the Oxaliplatin HY-17371 -induced NF-?B transcriptional activity and potentiates Oxaliplatin-induced apoptosis in androgen-independent prostate cancer AIPC cells. AZ10397767 significantly inhibits neutrophil recruitment into tumors which then adversely affects tumor growth in vitro and in vivo.