Avapritinib (Standard)

Description

Avapritinib Standard is the analytical standard of Avapritinib. This product is intended for research and analytical applications. Avapritinib BLU-285 is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib BLU-285 binds the active conformation of the kinase and shows antitumor activity. Avapritinib BLU-285 attenuates the transport function of both ABCB1 and ABCG2.