ATG5 Knockout Immortalized Mouse Kidney Epithelial Cell Line

Description

Autophagy is a catabolic process in which proteins and cellular organelles are degraded under metabolic stress through the lysosomal pathway. Essential autophagy-related genes i.e. Atg 5 and Atg 7 play an important role in mammalian development, survival and maintaining metabolism and homeostasis. The Atg5 Knockout Immortalized Mouse Kidney Epithelial Cells Atg5-/- iBMK is derived from stable transformation of E1A and p53DD into primary kidney epithelial cells from C57B/6J mice deficient for Atg5. Together with the wild-type iBMK T0082 and Atg7 Knockout iBMK Atg7-/- iBMK, T3028 , these cell lines are suitable in studying the relationships between autophagy and tumor suppression/cancer cell survival.