![Anti-TRIP12/ULF antibody [EPR27062-86]](https://content.abcam.com/products/images/trip12-ulf-antibody-epr27062-86-ab313628--western-blot-img418406.jpg)
Anti-TRIP12/ULF antibody [EPR27062-86]
ab313628 · 20 µL
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Description
Anti-TRIP12/ULF antibody EPR27062-86 is a Rabbit Monoclonal antibody that is used in TRIP12/ULF Flow Cytometry Intra , ICC/IF, IHC-P, Western Blot. Suitable for Human, Mouse, Rat samples. Thyroid hormone receptor interactor 12 TRIP12 is an E3 ligase most notably involved in the proteolytic degradation of the tumor suppressors p14ARF and p19ARF. TRIP12 responds to DNA damage and oncogenic stress by targeting RNF168 and p19ARF for proteolysis. TRIP12 inactivation causes FBW7 protein accumulation and increased proteasomal degradation of the SCFFBW7 substrate Myeloid Leukemia 1 MCL1 , and sensitizes cancer cells to anti-tubulin chemotherapy. Conversely, TRIP12 is associated with distant metastasis-free survival in breast cancer, suggesting an inhibitory role in metastasis.
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