

Y058362 · 100 uL
abm good · Cat: Y058362
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abmgood.com/anti-smad7-antibody-y058362.htmlDescription
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 TGFBR1 , leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 CRCS3 . Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jun 2010


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