Anti-NOTCH3 antibody [EPR25183-101]

Description

Anti-NOTCH3 antibody EPR25183-101 is a Rabbit Monoclonal antibody that is used in NOTCH3 Flow Cytometry Intra , IHC-P, Western Blot. Suitable for Human samples. NOTCH3 is a cell-surface receptor that is widely expressed on vascular smooth-muscle cells. Mutations in the NOTCH3 gene are primarily reponsible for the development of CADASIL syndrome, a rare but devastating cerebrovascular disorder that provides an opportunity to understand the mechanisms underlying other types of small-vessel arteriopathies, vascular dementia, and the relationship between migraine and stroke. Therapeutic antibodies targeting NOTCH3 are being investigated for both CADASIL and a wide range of cancer types.