GENERAL CATALOGUE
AMN082 free base
HY-103565A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-103565A
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medchemexpress.com/amn082-free-base.html
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Catalog No: HY-103565A
CAS No: 83027-13-8
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTP?S binding EC50 values, 64-290 nM at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.
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