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Brand Store/abcam/AMN082 dihydrochloride, mGlu7 agonist
AMN082 dihydrochloride, mGlu7 agonist
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AMN082 dihydrochloride, mGlu7 agonist

ab120011 · 10 mg

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Catalog No: ab120011
Category: Biochemicals
Pack Size: 10 mg
Brand: abcam

Description

MW 465.5 Da, Purity >98 %. Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding EC50 = 64-290 nM in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4,5, 6, and 8, ionotropic receptors up to 10 muM . Elevates plasma stress hormones in vivo. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones.

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