GENERAL CATALOGUE
AF151
HY-174873 · 50 mg
MedChemExpress · Cat: HY-174873
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medchemexpress.com/af151.html
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Catalog No: HY-174873
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
AF151 is a METTL3 PROTAC degrader with the DC50 of 0.43 ?M in MOLM-13 cells. AF151 inhibits cell growth by significantly degrading METTL3 protein and reducing m6A levels. AF151 can induce cell apoptosis and reduce the level of Bcl-2 protein. AF151 can be used for research on cancer such as acute myeloid leukemia AML . Pink: METTL3 Ligand HY-174874 ; Blue: VHL Ligand HY-125845 ; Black: Linker; VHL Ligand+Linker HY-174875 .
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