A11

Description

A11 ANXA1-derived 11 amino acidAAasAasAalong peptide is an ANXA1-EphA2 interaction blocker peptide. A11 decreases ANXA1 bound to EphA2 and increased Cbl an E3 ubiquitin ligase of EphA2 bound to EphA2. A11 efficiently decreases EphA2 level, and substantially increases EphA2 ubiquitination. A11 increases EphA2 internalization and colocalization of EphA2 and Cbl in the NPC cells. A11 inhibits nasopharyngeal carcinoma NPC cell proliferation, migration and invasion. A11 inhibits angiogenesis.