A-485
ab287107 · 1 mg
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Description
MW 536.5 Da, Purity >98 %. A potent and selective p300/CREB-binding protein CBP HAT domain inhibitor IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 BHC and p300-BHC domains, respectively . A-485 displays > 1000-fold selectivity over closely related HATs. It decreases acetylated histone H3 lysine 27 H3K27Ac , but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer NSCLC , small cell lung cancer, triple-negative breast cancer, mantel cell lymphoma, multiple myeloma, non-Hodgkins, and acute myeloid leukemia cell lines.
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