3?,4?,7-Trihydroxyflavone

Description

3?,4?,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 IC50 = 1.89 ?M and COX-1 IC50 = 36.37 ?M . 3?,4?,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-?. 3?,4?,7-Trihydroxyflavone inhibits H2O2-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3?,4?,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3?,4?,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3?,4?,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine HY-N0296 -induced memory deficits in mice.