GENERAL CATALOGUE
2-APQC
HY-158426 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-158426
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Manufacturer product page
medchemexpress.com/2-apqc.htmlCatalog No: HY-158426
CAS No: 500271-63-6
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
2-APQC is an orally active and selective agonist of Sirtuin-3 SIRT3 Kd=2.756 ?M , antagonizes Isoproterenol/ISO HY-B0468 -induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-?/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure.
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